VivaSlim - First human evidence of the benefits of calorie restriction
by faina marco (2021-03-16)
Living longer and better almost necessarily means eating less. In the last decade, numerous scientific groups have tested so-called caloric restriction in animals, a strategy consisting in reducing food intake to observe the effects on metabolism. All these studies clearly indicated that oxidative stress was reduced in tissues and organs of animals, thereby reducing the risk of degenerative diseases and lengthening life. The problem was, there was still no conclusive evidence or studies in humans, but the team of researcher Leanne M. Redman just published the first significant evidence in a clinical trial with people.
Volunteers lost an average of 9 kilos and felt better overall
In a paper published this Thursday in the journal Cell Metabolism, Redman's team describes an experiment carried out for two years with a group of 53 volunteers who reduced their caloric intake by 15 percent and whose metabolites they analyzed isotopically every two weeks. The result was that these people, in addition to losing an average of 9 kilos (which was not part of the objective because it was not a diet), experienced a decrease in oxidative stress in the cells of their body, which in previous experiments was It has been shown to be a determining factor in the development of age-related diseases such as Parkinson's or Alzheimer's.
"Lowering your calorie intake can slow down your basal metabolism and, if the products of that metabolism accelerate the aging process, the caloric restriction maintained over the years can help reduce the risk of chronic diseases and extend life ", Redman says. The trial, dubbed CALERIE (the acronym for Comprehensive Assessment of Long-Term Effects of Reduced Energy Intake) is the first randomized controlled trial of the effects of caloric restriction in non-obese humans.
This is the first randomized controlled trial of the effects of caloric restriction in non-obese humans
The volunteers, men and women between the ages of 21 and 50, did not experience any adverse effects as a result of the procedure, such as anemia, bone loss or menstrual disorders. In fact, the authors note, the two trials produced improvements in overall mood and health-related quality of life. "We've seen that even people who were already healthy and lean can benefit from a calorie restriction regimen," says Redman. And incidentally, he concludes, the result reinforces the theories that link low metabolism with greater longevity and the theory of oxidative damage.
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